Annales françaises d’anesthésie et de réanimation – Vol. 27 – N° 5 – p. – Une acidose lactique sévère compliquant une leucémie aiguë – EM|consulte. La leucémie est la forme de cancer la plus souvent diagnostiquée chez les enfants, et la leucémie lymphoblastique aiguë, ou LLA comme on l’appelle. Les leucémies de l’enfant» propose un état des connaissances sur la maladie et sa prise en charge: quels sont les facteurs de risque, les symptômes et outils.
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Prognosis Prognosis varies widely according to cytogenetics, molecular findings, response to induction treatment and age, between others.
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That means that AML could be the consequence of at least 2 different types luecemie gene mutations. Other search option s Alphabetical list. Additional information Further information on leycemie disease Classification s 2 Gene s 34 Other website s 2. After morphological examination, immunophenotyping of leukemic cells, cytogenetic and molecular analysis should be performed. Acidosis, Lactates, Acute leukemia.
Acute myeloid leukemia AML is a group of neoplasms arising from precursor cells committed to the myeloid cell-line differentiation. Top of the page – Article Outline.
Extramedullary accumulation of myeloid blasts in different tissues, mainly skin, can be observed and is known as myeloid sarcoma see this term. Disease definition Acute myeloid peucemie AML is a group of neoplasms arising from precursor cells committed to the myeloid cell-line differentiation.
Some drugs such as azacitidine or decitabine are available for the treatment of elderly AML patients under specific circumstances. The owners of this website hereby guarantee to respect the legal confidentiality conditions, applicable in France, and not to disclose this data to third parties. Etiology Pathogenesis of AML is still unclear but a two-hit model has been suggested as the probable mechanism for leukemogenesis.
AML manifests by fever, pallor, anemia, hemorrhages and recurrent infections. Testes are usually not affected. Only comments seeking to improve the quality and accuracy of information on the Orphanet website are accepted. Based on stratification, patients can be treated with chemotherapy consolidation or allogenic hematopoietic stem cell transplantation HSCT.
Differential diagnosis Differential diagnosis includes megaloblastic anaemia, myelodysplastic syndromes, acute lymphoblastic leukemia, acute biphenotypic leukemia, chronic myeloid leukemia myeloid blast phaseand metastases of tumors such rhabdomyosarcoma and neuroblastoma leuvemie these terms.
Central nervous system infiltration is uncommon and mainly related with monocytic variants. Diagnosis of AML also relies on bone marrow aspirate or biopsy after the disease has been suspected. Contact Help Who are we?
You may thus request that your data, should it be inaccurate, incomplete, unclear, outdated, not be used or stored, be corrected, clarified, updated or deleted. Acidosis, Lactates, Acute leukemia Outline. Check this box if you wish to receive a copy of your message.
Although, AML can occur at any age, it is typically a disease affecting elder people, usually more than 65 years.
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Differential diagnosis includes megaloblastic anaemia, myelodysplastic syndromes, acute lymphoblastic leukemia, acute biphenotypic leukemia, chronic myeloid leukemia myeloid blast phaseand metastases of tumors such rhabdomyosarcoma and neuroblastoma see these terms.
Refractory or relapsed AML is treated with a second induction course adding new drugs such gemtuzumab ozogamicin to the standard treatment. Clinical description Although, AML can occur at any age, it is typically a disease affecting elder people, usually more than 65 years. Diagnostic methods Diagnosis relies on laboratory findings showing anemia, thrombocytopenia and leucopenia or leukocytosis which result from disturbed hematopoietic function due to bone marrow and peripheral blood infiltration by immature blast cells.
Summary and related texts. The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment.
Leucémie aiguë promyélocytaire
Journal page Archives Contents list. Prognosis of elder patients is rather poor. Class I mutations resulting in proliferative advantage leuceie the class II mutations alter the normal hematopoietic differentiation. All of them are characterized by clonal expansion of myeloid blasts.
AML Acute myelogenous leukemia Prevalence: Pathogenesis of AML is still unclear but a two-hit model has been suggested as the probable mechanism for leukemogenesis.