climatic droplet keratopathy and pterygium was examined in a group of Climatic droplet keratopathy was seen especially in aboriginal males who had worked. PDF | On Jan 1, , Khalid F Tabbara and others published Climatic Droplet Keratopathy. The band-shaped bilateral corneal opacities that sometimes develop in certain geographically defined parts of the world are characterized by the deposition of.

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Similar results were obtained when corneal epithelial cells were exposed to UVR in vitro [ 4849 ].

No disease was found in region 4 where individuals work outdoors, have balanced diet, and use eye protection. To summarize, the CDK existence was related not only to climate but also to the dietary habits and lack of protection from sunlight. Create a free personal account to make a comment, download free article PDFs, sign up for alerts and more. The Academy uses cookies to analyze performance and provide relevant personalized content to xlimatic of our website.

Although the disease is slow in progression, significant visual compromise is a long-term consequence in untreated patients, especially in areas of the world with severe environmental or climatic exposure. The exact aetiology and pathogenesis of CDK are unknown, but they are possibly multifactorial. In the secondary corneal form, the lesions are usually located at sites of previous pathology, dlimatic as trauma, neovascularization, or inflammation, and it can be presented either unilateral or bilateral depending on the etiology of prior lesion.

The values of UVR can be calculated at ground level using radiometers or computer programs that manipulate different variables such as ozone, latitude, date, time, and cloudiness, among others [ 66 ]. View at Google Scholar N. Demographic data and prevalence of CDK in the four Argentinean regions. A deeper knowledge of CDK pathogenic mechanisms will provide new therapeutic strategies. The degraded protein material may then be deposited in the superficial stroma. In general, the visual acuity is severely affected by this stage.


InBaquis [ 1 ] described for the first time an acquired degenerative disease of the human cornea colloid degeneration of the corneapotentially disabling and being characterized by a slow progression to corneal opacity. All patients completed a questionnaire related to diet, work activity, and the wear of eye protection sunglasses, hats during their entire life. Purchase access Subscribe to the journal. Elevated lesions may progress to complications such as epithelial defects, recurrent corneal erosions, or sterile ulceration.

UV light is now widely accepted to be the main etiological factor in the pathogenesis of CDK. In addition to the findings related to the cornea, the solar radiation that chronically reaches the bottom and most exposed part of the iris could play an important role in inducing depigmentation or atrophy in superficial layers, as previously observed in some patients with CDK [ 35 ]. Based upon our results, which clearly demonstrate the existence of CDK only in one out of four Argentinean regions with similar climates, it should be worth considering that a proper name for this corneal pathology should be environmental droplet keratopathy or environmental proteinaceous corneal degeneration, rather than climatic droplet keratopathy because its genesis is not only related to the climate.

Eye diseases in which sunlight is implicated are called ophthalmoheliosis, with these conditions representing important eye health hazards in many communities worldwide. The indemnity of the superior cornea, protected by the eyelid, suggests an etiologic factor contributing to chronic corneal exposure to ultraviolet radiation UVR and other stresses.

Treatments may include superficial keratectomy, phototherapeutic keratectomy, lamellar keratoplasty, or penetrating keratoplasty in the most climativ cases.

In contrast, individuals inhabiting region 4 have a balanced diet meat, vegetables, cereals, and fruit Table 3.

BioMed Research International

Assigned status Up to Date by Danny A. The soil is clayey-sandy and covered by low shrub or steppe vegetation. Since the only treatment in advanced cases is a corneal transplantation, which in different impoverished regions of the world is not an available option, the implementation of simple preventive measures such as proper eyes protection and adequate diet droolet normal levels of AA would contribute to eradication of this disease.


The coalescence and increased volume of these spherules may cause the disruption of Bowman’s membrane and the elevation and thinning of the corneal epithelium. Conversely, region keraotpathy individuals had balanced diet and higher sAA concentrations. Montezuma, MD Assigned editor: Purchase access Subscribe to the journal.

Get free access to newly published articles Create a personal account or sign in to: We have recently shown elsewhere that, in patients with CDK, a hypersensitive reaction occurred in the cornea with the initial participation of important proinflammatory components of the innate immune system [ 52 ]. For these reasons, in the present investigation we did not calculate the UVR values at ground level for any of the four Argentinean regions. Our website uses cookies to enhance your experience.

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Climatic droplet keratopathy: an old disease in new clothes.

We have also investigated matrix metalloproteinases MMP and their inhibitors, TIMP, in patients with CDK, because these molecules control the degradation of the corneal epithelium and stroma.

Create a personal account to register for email alerts with links to free full-text articles. However, association does not necessarily mean causation.

The questionnaire about food consumption clearly indicated a dietary deficiency drpolet rich vitamins foods, especially AA, in individuals from regions 1, 2, and 3.