LRRTM1 leucine rich repeat transmembrane neuronal 1 [ (human)]. Gene ID: , updated on 7-Dec This gene is imprinted, being predominantly expressed from the paternal allele and showing a variable pattern of maternal down-regulation. May be associated . Leucine-rich repeat transmembrane neuronal protein 1. Gene. Lrrtm1. Organism. Mus musculus (Mouse). Status. Reviewed-Annotation score: Annotation.

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It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.

C2 is a human fibroblast cell line. Brain asymmetry Dual brain theory Bicameralism. If the zoom level is high enough, it can show the nucleotides at the corresponding location, or a graphical encoding for each nucleotide A: Family-based association study of markers on chromosome 22 in schizophrenia using African-American, European-American, and Chinese families.

The haplotype varied in frequency between 7. Leucine-rich repeat lrtm1 neuronal protein 1.

LRRTM1 leucine rich repeat transmembrane neuronal 1 [ (human)]

However, biallelic expression was found in 15 out of 18 brains, and LRRTM1 was expressed at similar levels from both alleles in the adult human cerebral cortex of five individuals showing biallelic expression analyzed by quantitative PCR.

Our website will not work properly. October 1, Last modified: This is the first potential genetic influence on human handedness to be identified, and the first putative genetic effect on variability in human brain asymmetry. LRRTM1 is the first gene linked to increased odds of being left-handedwhen inherited from the father’s side.

This is version of the entry and version 1 of the sequence. Abstract Left—right asymmetrical brain function underlies much of human cognition, behavior and emotion. In developing mice, Lrrtm1 was expressed at embryonic day 13 and Please consider upgrading your browser.


LRRTM1 leucine rich repeat transmembrane neuronal 1 [ (human)]

Similarly to embryonic brain, LRRTM1 was expressed at similar levels that is, symmetrically in all analyzed regions of left and right adult human cerebral cortex several different cortical regions from five individuals were analyzed by quantitative PCR.

IPR Leucine-rich repeat, typical subtype.

Left—right asymmetrical brain function underlies much of human cognition, behavior and emotion. Clicking on this track shows additional information and links for more information.

This association is likely to be partly genetic in etiology.

Ensembl growth cone Source: Discussion Crow proposed that handedness, brain asymmetry and schizophrenia share an underlying genetic relationship. Protein interaction database and analysis system More Four Gwne in distinct locations rs, rs, rs and rs; Table S1which were not in significant linkage disequilibrium LD with one another, showed nominally significant paternal-specific association with relative hand skill 0.

December 5, This is version of the entry and version 2 of the sequence. It is useful for tracking sequence updates. Database of Orthologous Groups More Lrrtm1 interacts with markers MirMirMirSupplementary Information doc 86K Click here to view. Human Protein Atlas More More caudal still cthalamic signal shifts ventrally to a structure consistent with the lateral lrgtm1 body. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Lrrtm1 MGI Mouse Gene Detail – MGI – leucine rich repeat transmembrane neuronal 1

You are using a version of browser that may not display all the features of this website. These are stable identifiers and should be used to cite UniProtKB entries.


A bonus to all MIMmatch users geene the option to sign up for updates on new gene-phenotype relationships. Search for genome features by name, symbol, synonym, homolog, allele, or accession ID: Comparative Toxicogenomics Database More Live-cell staining for overexpressed LRRTM1 in DRG neurons revealed that the protein is not accessible on the plasma membrane under conditions that allowed surface detection of a related member of the LRR protein superfamily, Lingo1 Figure 5. Parent-of-origin effects on handedness and schizophrenia susceptibility on chromosome 2pq Independent genome-wide scans identify a chromosome 18 quantitative-trait locus influencing dyslexia.

Leucine-rich repeat transmembrane neuronal protein 1

The left-handedness risk haplotype is highlighted in bold. March 6, Last modified: We used the total, paternal and multi-allelic options of QTDT together for the association tests. Q8K Primary citable accession number: In the present study we have used genetic association mapping and gene-functional analysis to identify a novel imprinted gene on 2p12, LRRTM1, that we propose is responsible for causing the linkages of this chromosomal region to genr handedness and schizophrenia.

Protein Spotlight The hands to say it – Issue 91 of February It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.