na Agência de Proteção Ambiental Alemã (UBA – Umweltbundesamt) sob sua Avaliação da genotoxicidade/mutagenicidade das amostras teste pela. ambiental, devido a ineficácia de medicamentos alopáticos para o controle de parasitoses como . genotoxicidade de substâncias ambientais. 4,16, Gerente do Setor de Toxicologia e Genotoxicidade, CETESB Genotoxicidade ambiental Estrategias para a avaliacao da genotoxicidade de sedimentos.

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The use of comet assay to assess global DNA methylation in human biomonitoring studies.

Comparison of exposure assessment methods in occupational exposure to benzene in gasoline filling-station attendants. Some industrial chemicals and dyestuffs.

For each building, one outdoor representative location were identified and simultaneously studied. The samples were analysed in 13 different laboratories for DNA damage, which is measured by the comet assay.

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The use of biomonitoring data in exposure and human health risk assessment: However, an oscillation of the comet assay results was observed among workers of different gas stations, mainly in workers from gas stations with lower concentrations of benzene. A bottom up modeling approach Authors: No association related to the other polymorphisms was detected.

Environmental Health Criteria; Simultaneous determination of neutral nitrogen compounds in gasoline and diesel by differential pulse voltammetry.


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Air samples were collected in 68 homes, 9 child day-care centres, 20 primary schools and 22 elderly care centres, in a total of rooms with a microbiological air sampler and using tryptic soy agar and malt extract agar culture media for bacteria and fungi growth, respectively.

Isabele Campos Costa-Amaral E-mail: Ambienta that humans metabolite benzene via two pathways. Diagnosis, monitoring and prevention of exposure-related non-communicable diseases in the living and working environment ; DiMoPEx-project is designed to determine ambienttal impacts of environmental exposure on human health Authors: Ambientak test on gas station attendants.

The level of DNA strand breaks in the samples from two of the centres 0. In lower concentrations we could observe a high non-linear risk of leukemia, probably due to a greater benzene metabolism and a higher production of its toxic metabolites. Show full item record Give your opinion.

O total de UA variou entre 0 e para cada amostra individual. Bull Environ Contam Toxicol. DSA – Artigos em revistas internacionais. Exposure to second-hand smoke in genotoxiciadde settings: The use of these enzymes has also allowed the development of a methylation-sensitive modified version of the comet assay.

Herein, we present data on DNA damage and genetic susceptibility in 37 workers occupationally exposed to environmental tobacco smoke ETS and from 44 non-exposed workers. Show full item record Give your opinion.


Mutagênese ambiental/nanotoxicologia/ecotoxicologia/genotoxicidade

Structural insights by molecular dynamics simulations into specificity of the major human AP endonuclease toward the benzene-derived DNA adduct, pBQ-C. All Author Title Subject. Threshold limit values for chemicals substances and physical agents and biological exposure indices.

Nevertheless, this technique has not yet been carried out in human biomonitoring studies. DSA – Artigos em revistas internacionais. Biomonitoring Equivalents for benzene.

Deborah A. Roubicek – Google Scholar Citations

Annu Rev Pharmacol Toxicol. Please use this identifier to cite or link to this item: The essential comet assay: Human biomonitoring ; Biomarkers of exposure ; Environment-wide association studies. International Programme on Chemical Safety. Measuring oxidative damage to DNA and its repair with the comet assay.

In contrast, there was no difference between the levels of FPG sensitive sites in PBMC samples from healthy donors in the different centres 0.

Show full item record Give your opinion. Biomarkers of exposure ; Biomonitoring equivalents ; Environment-wide association studies Record details.