Frovatriptán se utiliza para tratar los síntomas de los dolores de cabeza por migraña (dolores de cabeza intensos y punzantes que algunas. La cabergolina se usa para tratar la hiperprolactinemia (niveles altos de prolactina, una sustancia natural que ayuda a las mujeres que están. Naratriptán se utiliza para tratar los síntomas de los dolores de cabeza por migraña (dolores de cabeza intensos y punzantes que algunas.

Author: Arashishakar Kell
Country: Lesotho
Language: English (Spanish)
Genre: Life
Published (Last): 22 August 2017
Pages: 392
PDF File Size: 13.46 Mb
ePub File Size: 20.76 Mb
ISBN: 928-8-54547-904-3
Downloads: 77590
Price: Free* [*Free Regsitration Required]
Uploader: Arashilar

At examination, she presented with loss of muscular strength on upper limbs, intense pain in lower limbs, below the knee, cyanosis of the toes and absence of distal pulses. Ueberall MA, Wenzel D.

Ergotamine was discontinued, ergotamiba well as the use of heparin, cilostazol and buflomedil. After drugs were suspended and anticoagulants, vasodilators and antiplatelet drugs were prescribed, the patient progressed with improvement of pain, paresthesia and return of normal skin color and distal pulses in lower limbs.

All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License. Ergotamine derivatives include several drugs widely used in the treatment of acute migraine attacks. When arterial spasm is observed, especially if it is bilateral and symmetrical, intoxication by ergotamine should be suspected. Do children with migraine respond to oral sumatriptan differently from adults?

The fast absorption of the drug and ergotammina prolonged effects on the arterial network suggest that both the tight binding to its receptor and the presence of active metabolites in the blood circulation prolong its vasoconstrictor effect.

Edison Barreto de Souza Av.

J Clin Psych ; A double-blind study of subcutaneous dihydroergotamine vs subcutaneous sumatriptan in the treatment of acute migraine. She underwent arteriography, which showed both lower limbs with: The first and most important step in the treatment is to discontinue the causing agent; however, vasodilating therapy is fundamental for the improvement of the patient’s clinical status.


In recent publications, percutaneous angioplasty has been reported as an adjuvant intoxiczcion for arterial spasm; however, due to the risk of injury to the intimal layer of the vessels, consequently causing thrombosis, it should be avoided whenever possible.


Prostaglandins, ergot, alkaloids and other drugs. Sumatriptan in clinical practice: Sin embargo, no parecen ser necesarios reajustes en las dosis. During the Middle Ages the first descriptions of intoxication caused by ergotamine derivatives were made. Its active components are alkaloids, all derived from lysergic acid. Ergotamine derivatives include several drugs widely used in the treatment of acute migraine attacks and post-partum hemorrhage.

Intranasal sumatriptan for the acute treatment of migraine in children.

Acute arterial occlusion caused by ergotamine derivatives

Despite the fact that acute arterial occlusion caused by ergotamine derivative is a rare clinical condition, it should be considered in the differential diagnosis of ischemic syndromes, especially in young patients without cardiovascular risk factor, or of severe arterial embolism.

Ergotism with ischemia in all four extremities: Treatment options include anticoagulants such as heparin, oral vasodilators, platelet antiaggregants, anesthetic blocks, calcium channel blockers, hyperbaric intoxicaacion, as well as intravascular volume expansion. The authors report the case of a year old patient with acute arterial occlusion in lower limbs secondary to the use of ergotamine derivatives.

Ergotism, ergotamine, ischemia, arterial insufficiency, arterial occlusion. In the pharmacological basis of therapeutics.

Manuscript received Mar 22,accepted for publication Jun 4, Differential diagnosis is necessary, since occlusive atherosclerotic disease, thromboembolic disease, arteritides, fibromuscular dysplasia and the Raynaud’s phenomenon all have vasospastic symptoms similar to those of ergotism. Introduction During the Middle Ages the first descriptions of intoxication caused by ergotamine intxoicacion were made. En muchos casos, la dosis de mg no ocasiona mejores resultados que la dosis de 25 mg.

Intoxication by these substances generally results from chronic administration, promoting symptoms secondary to arterial spasm and the consequent distal ischemia. Estos casos suelen ser muy raros, teniendo lugar preferentemente en pacientes con enfermedad arterial coronaria o en pacientes que han sido tratados con ergotamina en las 24 horas anteriores.


The objective of this study is to report a case of acute arterial occlusion of lower limbs as a consequence of the use of ergotamine tartrate, an infrequent condition, so that it can be diagnosed and treated as efficiently and early as possible. Despite nitroprusside being considered an antidote for ergotism due to its efficient action over the vascular smooth muscle, it is used only for severe cases because ergotamin problems with dosage, need for an infusion pump and multiple side effects.


There was no previous history of smoking, heart disease or intermittent lntoxicacion, but the patient reported a history of migraine with chronic use of ergotamine tartrate. Despite the multiple symptoms of ergotism, peripheral ischemia secondary to vasospasm is the most frequent and it affects 0.

A year-old female patient was admitted with a sudden onset of paresthesia in upper and lower limbs with 4 days of evolution. Vascular spasm and gangrene during heparin-dihydro-ergotamine prophylaxis.


On the one hand, ergotamine derivatives may damage the vascular endothelium by inducing the proliferation of arterial muscle cells due to stimulation of the platelet-derived growth factor and, on the other hand, they cause thrombosis and necrosis of the tunica media; these are symptoms associated with poisoning by ergotamine.

Lack of an interaction between sumatriptan and selective serotonin reuptake inhibitors.

The patient progressed with improvement of pain and upper and lower limb paresthesia, return of normal skin color and of distal pulses in the lower limbs; she was discharged on the sixth hospital day. Ergot is produced by a fungus Claviceps purpurea that grows on rye and other cereal plants.